Why You Wake Up Between 2 and 4 AM

Your liver is a metabolic powerhouse with its own circadian rhythms. Between roughly 1 and 3 AM, its processing toxins, managing hormones, and fine-tuning your internal chemistry. If the liver is overwhelmed, due to fatty buildup (e.g., MASLD), toxin exposure, poor nighttime eating patterns, or even shift work, it can disrupt sleep.